Yog vim li cas kojic acid dipalmitate ua nrov tshaj kojic acid hauv tshuaj pleev ib ce

1. Kojic Acid Dipalmitate yog dab tsi?

Cas No.:79725-98-7

Cov mis mos molecular: C38H66O6

Molecular Luj:618.93

Kojic acid dipalmitate yog ib qho derivative ntawm kojic acid thiab fatty acid (palmitic acid), thiab ib qho ntawm ntau yam peb siv los txo cov teeb meem ntawm hyperpigmentation.

Nws yog cov hmoov dawb dawb uas muaj peev xwm tiv thaiv oxidant zoo heev.

Nws yog ib qho ntawm peb cov khoom muag kub muag tshuaj pleev ib ce.

Cov neeg siv Kojic acid dipalmitate dav hauv cov tshuaj pleev ib ce kom pom thiab txawm tawm ntawm daim tawv nqaij thiab kho pob txuv nti, sunburns, thiab hnub nyoog me ntsis.

Nws yog suav hais tias yog ib qho ntawm cov neeg nyiam tshaj plaws thiab ua tau zoo ntawm daim tawv nqaij-dawb huv hauv kev lag luam tshuaj pleev ib ce.

Cov kev tshawb fawb tau pom tias tom qab sib txuas kojic acid palmitate nrog glucosamine derivatives, nws cov nyhuv whitening yuav nce exponentially.

Kojic acid palmitate yog superior rau kojic acid nyob rau hauv daim tawv nqaij dawb thiab koj xyuas lawv qhov sib txawv hauv qab no.

2. Kojic acid dipalmitate vs kojic acid

Kojic acid palmitate yog ib qho derivative ntawm kojic acid thiab nws tau suav hais tias yog qhov zoo tshaj plaws kojic acid version hauv kojic acid tsev neeg txog tam sim no.

Los ntawm cov saum toj no, koj tuaj yeem pom lawv cov qauv sib txawv.

Ntawm no peb hla lawv qhov sib txawv ntawm lub cev thiab tshuaj lom neeg xws li qhov hnyav molecular, cov mis mos molecular, thiab lwm yam, peb tsuas yog sau lawv qhov sib txawv thaum lawv siv hauv tshuaj pleev ib ce raws li hauv qab no:

#1 Cov dej sib txawv

Kojic acid dipalmitate yog lipid-soluble tshuaj insoluble hauv dej los yog ethanol.

Yog tias koj xav siv nws rau daim tawv nqaij-dawb, koj yuav tsum xaiv cov roj pleev xim los yog cov tshuaj pleev ib ce, los yog nws yuav tsis yaj thiab nqus los ntawm koj cov tawv nqaij kom ua tiav cov nyhuv whitening.

Thaum Kojic acid yog insoluble hauv lipids tab sis soluble hauv dej.

Yog li sib tov kojic acid rau hauv koj cov dej-raws li cov tshuaj pleev ib ce.

#2 Pigmentation thiab melasma tshem tawm cov teebmeem

Kev sim tshuaj ntsuam xyuas tau pom tias qhov ua tau zoo ntawm kojic acid dipalmitate yog tshaj 50 feem pua, thiab tag nrho cov txiaj ntsig tau zoo tshaj 90 feem pua, tab sis cov nyhuv ntawm kojic acid yog qis dua.

#3 Whitening efficiency

Kojic acid ester muaj zog inhibitory nyhuv ntawm melanin ntau lawm tshaj kojic acid.

Piv txwv li, kojic acid dibutyrate ester yog ob zaug muaj zog hauv kev tso tseg melanin ntau lawm raws li kojic acid

#4 Stability

Raws li ester, Kojic acid dipalmitate yog ruaj khov dua kojic acid.

Vim tias muaj ob pawg hydroxyl hauv kojic acid hauv kojic acid, kojic acid yooj yim dua rau oxidized los hloov xim lossis nws tus cwj pwm, thaum kojic acid dipalmitate nyuaj rau oxidized los ua lwm yam thaum ob pawg hydroxy no tiv thaiv, ces nws tsis tshua muaj rau kojic acid palmitate mus daj los yog phem thaum raug huab cua, tshav kub, lub teeb, thiab noo noo.

Ntxiv rau, kojic dipalmitate yuav tsis chelate nrog ntau cov hlau ions zoo li kojic acid ua nyob rau hauv cov tshuaj pleev ib ce, yog li kojic dipalmitate lotion yuav tsis yooj yim mus daj los yog hloov xim piv nrog cov tshuaj pleev ib ce ua los ntawm kojic acid.

Ntxiv rau, kojic acid tsis ruaj khov nyob rau hauv ib puag ncig alkaline vim nws cov kua qaub, thaum kojic dipalmitate kuj ruaj khov dua thaum tus nqi ib puag ncig PH nyob nruab nrab ntawm 3 txog 10.

#5 Compatibility nrog rau lwm cov khoom xyaw whitening

Kojic acid palmitate yuav luag sib xws nrog cov tshuaj tiv thaiv thiab tshuaj pleev thaiv hnub siv rau cov tshuaj pleev ib ce.

Nws sib tov zoo nrog vitamin C, alpha arbutin, thiab vitamin C derivatives kom tau ib tug zoo-whitening nyhuv.

Kev tshawb fawb tau pom tias cov nyhuv ua ke-dawb huv tau nce exponentially.

#6 Kev nyab xeeb

Raws li ester, kojic acid palmitate yog nruab nrab rau koj cov tawv nqaij.

Tab sis koj cov tawv nqaij yuav khaus thaum raug cov mis uas muaj cov kua qaub xws li kojic acid, glycolic acid, thiab lwm yam.

Kev tshawb fawb pom tau hais tias Kojic acid daws yuav ua rau khaus lossis khaus rau koj cov tawv nqaij.

#7 Nqi thiab Purity

Tom qab ntau qhov zoo ntawm dipalmitate tshaj kojic acid, kojic acid hmoov muaj nws qhov zoo.

Kojic acid yog pheej yig dua, nws raug nqi li 1/9 ntawm dipalmitate hmoov.

Tsis tas li, qhov purity ntawm kojic acid hmoov yog 99 feem pua ​​​​li min, thiab dipalmitate kojic acid purity yog 98 feem pua ​​​​li min.

3. Kojic Acid Dipalmitate Ua Li Cas?

Ua ntej, peb tau txais palmitoyl chloride los ntawm PC13 thiab cov tshuaj palmitic acid.

Tom qab ntawd peb cia palmitoyl chloride hnov ​​​​mob nrog kojic acid kom tau cov khoom nyoos, thiab tom qab ntawd ntxuav thiab recrystallize nws kom tau cov ntshiab kojic acid dipalmitate crystals.

(1) Synthesis ntawm palmitoyl chloride

Ntxiv palmitic acid rau lub khob peb-caj dab, thiab yaj nws nrog CC14. Maj mam tso PC13 rau hauv lub khob los ntawm lub funnel.

Peb pib cov tshuaj tiv thaiv ntawm ib tug tsawg stirring ceev.

Tom qab ntawd thaum cov tshuaj tiv thaiv pib, peb cia lawv hnov ​​​​mob ntawm 54 ~ 55 degrees celsius rau ob peb teev.

Tom qab ntawd peb sov nws mus rau 60 degrees thiab cia cov tshuaj tiv thaiv mus rau lwm teev, ces peb nres cov tshuaj tiv thaiv thiab tshem tawm H3P03.

(2) Synthesis ntawm kojic acid dipalmitate

Ua ntej, dissolve kojic acid nyob rau hauv ib qho acetone / pyridine tov nyob rau hauv ib tug peb-caj dab, ces maj mam drip lub palmitoyl chloride los ntawm ib tug funnel thiab cia lawv hnov ​​nyob rau hauv chav tsev kub.

Thaum kawg ntawm cov tshuaj tiv thaiv, peb ntxuav lub hom phiaj nrog dej txias 3 zaug thiab lim nws ntawm Brinell funnel.

Thaum kawg, peb recrystallize thiab qhuav nws nyob rau hauv lub tshuab nqus tsev kom tau dawb flaky crystals.

Cov txiaj ntsig thiab qhov xaus:

(2.1) Cov dej tsis muaj tshuaj tiv thaiv

PCl3 yog cov kua uas muaj ntxhiab tsw, uas yuav decompose los tsim cov pa luam yeeb dawb thaum raug dej.

Cov khoom daj daj nyob rau hauv lub raj mis thaum lub sij hawm cov tshuaj tiv thaiv yog phosphoric acid.

Vim tias qhov ua haujlwm ntawm palmitoyl chloride thiab PCl3, peb yuav tsum ua tiav tag nrho cov txheej txheem kev sim nyob rau hauv qhuav qhuav.

(2.2) Qhov sib txawv molecular piv.

Thaum cov molar piv ntawm n (palmitic acid) / n (PCl3) yog 1: 2, cov tshuaj tiv thaiv muaj qhov hloov siab tshaj plaws thiab qhov purity ntawm palmitoyl chloride kwv yees li 95 feem pua ​​​​li min.

(2.3) Cov tshuaj tiv thaiv kub.

Thaum cov tshuaj tiv thaiv kub qis dua 55 degrees Celsius, cov tshuaj tiv thaiv chlorination tsis tuaj yeem ua tiav, thiab tsuas yog thaum qhov kub thiab txias siab tshaj 55 degrees thiab qhov kawg ntawm cov tshuaj tiv thaiv kub txog 60 degrees, cov tshuaj tiv thaiv chloride nyiam ua tiav.

Yog li, qhov ntsuas kub tsim nyog rau kev npaj ntawm palmitoyl chloride yog 55-60 degrees, thiab qhov kawg ntawm cov tshuaj tiv thaiv yuav tsum tau nce mus rau 60 degrees Celsius thiab khaws cia rau 1 teev kom tau txais txiaj ntsig siab tshaj plaws.

4. Yuav Ua Li Cas Dissolve Kojic Acid Dipalmitate Powder?

#1. Raws li kojic acid dipalmitate yog insoluble nyob rau hauv dej, nws yog ib qho nyuaj rau koj mus sib tov nws ncaj qha rau hauv cov tshuaj pleev ib ce dej.

Txawm tias thaum koj tswj kom muab sib xyaw rau hauv qee qhov, nws yooj yim rau nws tsim crystal precipitates tom qab.

Txhawm rau daws qhov teeb meem crystalization no, koj tuaj yeem ntxiv isopropyl palmitate lossis isopropyl myristate rau cov roj theem uas muaj kojic acid dipalmitate, kub cov roj theem mus rau 80 degree, thiab ua kom sov li 5 feeb kom txog thaum kojic acid dipalmitate yaj tag.

Tom qab ntawd ntxiv cov roj theem mus rau theem dej thiab emulsify li 10 feeb.

Tus nqi pH ntawm cov khoom kawg tau txais feem ntau yog nyob nruab nrab ntawm 5.0 thiab 8.0.

Qhov pom zoo koob tshuaj kojic acid dipalmitate hauv tshuaj pleev ib ce yog 3-5 feem pua.

#2. Lossis koj tuaj yeem sib tov kojic acid dipalmitate hmoov ncaj qha rau hauv koj cov cream kom tau 3 ~ 5 feem pua ​​​​ntawm cov tshuaj pleev xim dawb.

Noj 3 ~ 5g ntshiab kojic acid dipalmitate hmoov thiab sib tov rau hauv 100ml-cream los ntawm nplawm thiab co kom txog thaum tag nrho cov yaj.

Koj tuaj yeem yaj nws hauv cov roj dawb ua ntej ua ntej sib tov cov roj rau hauv cov tshuaj nplaum.

5. Cov txiaj ntsig

Stable ntawm pH 3 txog 10

Tsis complex nrog hlau ions thiab yuav tsis hloov xim

Lub teeb thiab kub ruaj khov

Tshaj nrog feem ntau cov khoom xyaw kom zoo nkauj.

6. Cov ntawv thov

Sunscreens thiab cov khoom tom qab tshav ntuj

Cov khoom pleev xim

Daim tawv nqaij lightening khoom

Anti-aging khoom

Creams thiab lotions

7.Yuav siv nws li cas?

Pib: Ntxiv txog 1 lub raj mus rau 4 oz ntawm koj nyiam lub hauv paus qab zib.

Advanced: Cov khoom xyaw no tau pom zoo siv txog li 5 feem pua ​​​​hauv cov qauv. Tsis txhob siv nyob rau hauv ib tug muaj zog concentration. Txhawm rau kom tau txais txiaj ntsig zoo tshaj plaws, yaj cov hmoov hauv cov roj dawb (xws li tshuaj pleev ib ce qib ntxhia roj lossis cov kua roj paraffin) ua ntej ntxiv rau cov tshuaj nplaum los yog roj raws li kev tsim. Peb pom zoo kom siv cov khoom xyaw no hauv cov qauv nrog pH ntau ntawm 4-7.