Chondroitin sulfate yog dab tsi.
Chondroitin sulfate (CS) yog ib chav kawm ntawm glycosaminoglycans uas tau txuas nrog cov proteins los tsim cov proteoglycans. Chondroitin sulfate yog dav faib nyob rau hauv extracellular matrix thiab cell nto ntawm cov ntaub so ntswg. Cov saw qab zib yog polymerized los ntawm alternating glucuronic acid thiab N-acetylgalactosamine, thiab txuas nrog serine residue ntawm cov core protein los ntawm ib cheeb tsam zoo li qab zib. . Txawm hais tias cov saw hlau tseem ceeb ntawm polysaccharide tsis yog qhov nyuaj, nws nthuav tawm qhov siab ntawm heterogeneity nyob rau hauv cov nqe lus ntawm qib sulfation, kev faib tawm ntawm pawg sulfate thiab rov sib txuas ntawm ob qhov sib txawv isomerized uronic acids. Cov qauv zoo ntawm chondroitin sulfate txiav txim siab qhov tshwj xeeb ntawm kev ua haujlwm thiab kev cuam tshuam nrog ntau cov protein molecules.
Peb siv tau li cas.
Lub ntsiab daim ntawv thov txoj hauv kev tshuaj yog raws li ib tug tshuaj rau kev kho mob ntawm ob leeg kab mob. Thaum siv nrog glucosamine, nws muaj cov txiaj ntsig ntawm kev txo qhov mob thiab txhawb kev tsim cov pob txha mos, thiab tuaj yeem txhim kho cov teeb meem sib koom ua ke.
Randomized placebo-tswj kev soj ntsuam kev sim tau pom tias chondroitin sulfate txo qhov mob, txhim kho kev sib koom ua haujlwm, txo kev sib koom tes o thiab kua dej ntau ntxiv hauv cov neeg mob osteoarthritis, thiab tiv thaiv qhov chaw hauv lub hauv caug thiab tes pob qij txha. Muab cov nyhuv cushioning, cushions cuam tshuam thiab kev sib txhuam thaum lub sijhawm txav, rub cov dej noo mus rau hauv cov molecules proteoglycan, thickens pob txha mos, thiab nce cov kua synovial hauv cov pob qij txha. Ib lub luag haujlwm tseem ceeb ntawm chondroitin yog ua raws li cov kav dej, xa cov pa oxygen tseem ceeb thiab cov khoom noj rau cov pob qij txha, pab tshem tawm cov khib nyiab ntawm cov pob qij txha, thiab tshem tawm cov pa roj carbon dioxide thiab cov khoom pov tseg tib lub sijhawm. Txij li cov pob txha mos pob txha tsis muaj ntshav, tag nrho cov pa oxygenation, khoom noj khoom haus, thiab lubrication yog los ntawm cov kua dej synovial.