Cycloastragenol hmoov

Khoom Taw Qhia

Astragalus is one of the commonly used Chinese herbal medicines. When used raw, it can help to strengthen the surface, diuretic and reduce swelling, and support toxins and promote muscle; Studies have shown that astragalus and its saponins have significant immune regulation, anti-inflammatory, antioxidant, anti-ischemic brain injury, anti-aging and nootropic effects. Astragalus saponins have been studied in depth at home and abroad, and dozens of astragalus saponins have been isolated and identified, such as acetyl astragaloside I, astragaloside I, II, astragaloside I-VIII, etc., astragaloside B, astragalus saponin I-XVI . Astragaloeide IV, also known as astragaloside IV, is an important saponin compound isolated from Astragalus with various pharmacological activities. It has a wide range of biological activities in the treatment of cardiovascular and cerebrovascular diseases, anti-aging, anti-inflammatory, analgesic, and immune regulation. However, the relative bioavailability of astragaloside in vivo is insufficient due to its relatively large molecular mass and inert solubility, which limits the development and promotion of its Chemicalbook as a drug. Astragaloside IV is a representative saponin component of traditional Chinese medicine Astragalus, and cycloastragenol is the sapogenin of astragaloside IV. Cycloastragaloside is the main hydrolyzed metabolite of astragaloside IV in the intestinal tract and absorbed into the blood component. It has a relatively small molecular mass and strong lipophilicity, which is conducive to biofilm penetration and gastrointestinal absorption to achieve better performance. bioavailability. A large number of modern medical studies have proved that astragaloside IV can reduce ischemia-reperfusion brain tissue damage by enhancing the body's ability to scavenge oxygen free radicals, inhibiting peroxidation, and reducing neuronal calcium overload. The research of Geron Biotechnology Company of the United States found that CAG has a significant telomerase activation effect. RevGenetics of the United States also confirmed through research that CAG is one of the raw materials of functional cosmetics and nutritional foods, and is currently the only one that can be used in The raw material for activating telomerase in human cells is a promising anti-aging substance.

Khoom Specification

1. Cov Khoom Siv Ua Haujlwm

Muaj nuj nqi

Raws li cov metabolite theem nrab nrog cov tshuaj muaj txiaj ntsig zoo hauv Astragalus, cycloastragalus muaj kev tiv thaiv ntawm cov kab mob plawv, mob stroke, fatty siab, plab aortic aneurysm thiab lwm yam kab mob, thiab tuaj yeem qhib telomerase thiab tswj kev tiv thaiv. , los txhawb kev kho mob thiab kev loj hlob ntawm cov plaub hau, thiab lwm yam. Txawm li cas los xij, tseem muaj qee qhov teeb meem hauv kev tshawb fawb tam sim no ntawm cov tshuaj pharmacological ntawm cycloastragalin:

1. Muaj feem xyuam hauv vitro thwmsim pom tias cycloastragalus muaj cytotoxicity ntawm ib qho concentration, qhia tias cycloastragal tsis muaj kev nyab xeeb kiag li, thiab nws toxicity rau hlwb xav tau kev tshawb fawb ntxiv, thiab nws txoj kev nyab xeeb hauv cov tsiaj yuav tsum tau tshawb xyuas ntxiv;

2. Kev tshawb fawb ntawm cycloastragal feem ntau yog txwv rau lub hom phiaj ua kom telomerase. Txawm hais tias nws muaj qhov zoo hauv kev txhim kho cov khoom kho mob ntsig txog, nws txwv nws txoj kev tshawb fawb tob thiab dav rau qee qhov. Txawm hais tias cyclic astragalus tau pom tias inhibit adenylate -activated protein kinase (AMPK) txoj hauv kev, farnesoid X receptor (FXR) transcription factor thiab silent mating type information regulator (silent mating type information regulation) SIRT1) protein regulator muaj ua qee yam tshuaj ntxiv rau nws lub hom phiaj pharmacological, tab sis tseem tsis muaj kev cuam tshuam txog kev ua haujlwm pharmacological thiab cov txheej txheem ntawm kev ua. Txawm hais tias tseem muaj qee qhov teeb meem hauv kev tshawb fawb txog cov tshuaj pharmacological ntawm cycloastragalus, nws yog qhov tsis lees paub tias nws yav tom ntej, nws yog ib qho tsim nyog los ntxiv dag zog rau kev tshawb fawb txog nws cov kev tiv thaiv kab mob xws li mob plawv, mob plawv tsis ua hauj lwm thiab arrhythmia, nrog rau kev tshawb nrhiav thiab kev tshawb fawb txog kev txhim kho cov kab mob plawv thiab kev tswj hwm endothelial cell homeostasis. Nws tuaj yeem siv tau zoo dua hauv kev kho mob. Nyob rau tib lub sijhawm, lub peev xwm ntawm cycloastragalus hauv kev kho mob cerebral ischemia thiab cov kab mob puas siab ntsws yuav tsum tau siv tag nrho, thiab nws cov txiaj ntsig ntawm cov kab mob cerebral neurovascular yuav tsum suav tias yog ib qho kev taw qhia tshiab rau kev tshawb fawb yav tom ntej.

Adaim ntawv thov

Nws tau txhim kho kev tiv thaiv kab mob, tiv thaiv daim siab, diuresis, tiv thaiv- laus, tiv thaiv- kev ntxhov siab, tiv thaiv kev mob ntshav siab thiab cov kab mob dav dav, thiab tuaj yeem cuam tshuam tus kab mob kev loj hlob thiab qog loj hlob. tuaj yeem txhim kho cardiopulmonary muaj nuj nqi, ntxiv dag zog rau lub plawv contractility, nthuav cov hlab ntsha, txhim kho daim tawv nqaij cov ntshav ncig thiab noj zaub mov zoo. Astragalus kuj induces interferon thiab mobilizes lub cev tiv thaiv kab mob. Ua kom muaj zog, tiv thaiv- qaug zog, ua kom hloov pauv, inhibit lub luag haujlwm ntawm osteoclasts.

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