Bacopa Monnieri Extract

Khoom Taw Qhia

Bacopa monnieri(Lub npe scientific: Portulaca oleracea L.) yog ib hom tshuaj ntsuab uas tau muab faib thoob plaws ntiaj teb. Cov tshuaj ntsuab ntawm Bacopa monnieri yog siv tshuaj los yog noj tau thiab tau siv dav hauv ntau yam tshuaj. Ntawm lawv, bioactive compounds muab rho tawm los ntawm Bacopa monnieri yog ib qho ntawm cov kev tshawb fawb hotspots tam sim no. Kab lus no yuav tham txog kev ua tau zoo ntawm Bacopa monnieri extract los ntawm peb yam: nws cov tshuaj muaj pes tsawg leeg, cov tshuaj pharmacological thiab cov txiaj ntsig kho mob.

Lub ntsiab chemical Cheebtsam ntawm Bacopa monnieri muaj xws li ib tug ntau yam ntawm biologically active tshuaj, xws li phytic acid, flavonoids (xws li apigenin, apigenin, thiab lwm yam), organic acids, alkaloids, monoterpenes, terpenoids, thiab triterpenoids sterols, polysaccharides thiab vitamins, thiab lwm yam. Cov tebchaw no ua lub luag haujlwm tseem ceeb hauv cov teebmeem ntawm Bacopa monnieri extract.

Khoom Specification

Product Function & Application

1. Pharmacological kev ua ntawm cov hlab ntsha

(1) Muaj txiaj ntsig zoo rau kev kawm thiab kev nco. Kev tshawb fawb qhia tau hais tias Bacopa monnieri thiab nws cov extracts muaj cov teebmeem hauv hlwb. Bacopa monnieri thiab nws cov ethanol extract tuaj yeem txhim kho kev kawm muaj peev xwm ntawm nas. Cov txiaj ntsig ntawm kev txhawb kev paub txog kev ua haujlwm feem ntau yog vim muaj ob lub saponins nquag ntawm Bacopa monnieri saponin A thiab B hauv ethanol extract. Ntxiv nrog rau kev txhawb nqa kev kawm thiab kev nco ua haujlwm ntawm cov nas ib txwm muaj, cov khoom xyaw nquag tuaj yeem cuam tshuam kev tsis nco qab (tsis nco qab) tshwm sim los ntawm scopolamine, electroshock thiab tswj kev ntxhov siab.

(2) Cov tshuaj tiv thaiv kev ntxhov siab Bacopa monnieri extract yog txawv ntawm benzodiazepine tshuaj tiv thaiv kev ntxhov siab. Cov qub tuaj yeem txhim kho kev paub txog kev ua haujlwm thaum tsim cov teebmeem tiv thaiv kev ntxhov siab, thaum tom kawg muaj cov teebmeem ntawm kev ua rau dementia. Ib tus nas tiv thaiv kev ntxhov siab txog kev sim qauv (siab ntxiv ntxiv rau cov qauv maze) tau siv los ua qhov kev tshawb fawb sib piv ntawm cov tshuaj tiv thaiv kev ntxhov siab ntawm BM standard extract thiab benzodiazepines. Cov nas tsuag tau hais lus 5, 10 thiab 20 mg / kg BM extract thiab intraperitoneally txhaj Lorazepam (LZP) 0.5mg / kg. Piv nrog rau lorazepam, high-dose Bacopa monnieri extract muaj zog tiv thaiv kev ntxhov siab vim thiab nws zoo dua li LZP. Bacopa monnieri tsis tsuas yog tsis ua rau dementia, Ntawm qhov tsis sib xws, nws tuaj yeem txhim kho lub cim xeeb ntawm cov tsiaj txhu thiab tib neeg.

(3) Antidepressant nyhuv: Methanol txheem extract ntawm Bacopa monnieri muaj ib tug muaj zog antidepressant nyhuv rau nas kev nyuaj siab qauv. Piv nrog rau cov tshuaj tiv thaiv kev nyuaj siab imipramine (15mg / kg), nws muaj txiaj ntsig zoo dua rau kev yuam ua luam dej thiab tau txais kev nyuaj siab tsis muaj zog. Hauv cov qauv, 20 lossis 40 mg / kg ntawm Bacopa monnieri tau muab ib zaug ib hnub rau 5 hnub, uas tuaj yeem tsim cov tshuaj tiv thaiv kev nyuaj siab.

(4) Cov nyhuv anticonvulsant ntawm Bacopa monnieri tau siv ib leeg lossis ua ke nrog phenytoin (ib qho tshuaj tiv thaiv kab mob uas ua rau lub hlwb tsis ua haujlwm), thiab tau soj ntsuam los ntawm kev ntsuas tus nas passive zam, qhov siab tshaj plaws ntawm electroshock epileptic qaug dab peg, thiab lub cev muaj zog. Cov txiaj ntsig tau pom tias , Phenytoin tuaj yeem ua rau kev paub txog kev ua haujlwm, thaum Bacopa monnieri tuaj yeem thim rov qab qhov kev puas tsuaj ntawm phenytoin ntawm kev paub txog kev ua haujlwm, txhim kho kev nco tau thiab nco khaws tshuaj, tab sis tsis cuam tshuam rau cov nyhuv anticonvulsant ntawm phenytoin; Bacopa monnieri tuaj yeem siv ib leeg lossis ua ke nrog lwm yam Kev siv ua ke ntawm cov tshuaj tiv thaiv kab mob vwm kuj tau lees paub tias Bacopa monnieri muaj zog tiv thaiv kab mob vwm thiab tuaj yeem kho qhov kev puas tsuaj rau kev paub txog kev ua haujlwm los ntawm cov tshuaj tiv thaiv kab mob vwm.

2. Cov nyhuv tiv thaiv qog: Bacopa monnieri extract tuaj yeem cuam tshuam kev loj hlob ntawm cov qog hlwb ntawm qhov tsis tshua muaj siab; toxicity ntawm high concentrations tseem xav tau ntxiv hauv vivo thwmsim kom meej. Cov tshuaj yuav ua haujlwm los ntawm inhibiting DNA replication.

3. Cov kev tshawb fawb txog kev tiv thaiv daim siab tau pom tias Bacopa monnieri tiv thaiv qhov inhibition ntawm antioxidant enzymes thiab txo qis glutathione ntau ntau, thiab inhibits qhov nce hauv peroxidized lipids tom qab kev tswj hwm morphine, yog li ua rau lub siab tiv thaiv morphine-induced lub siab lom hauv nas. nyhuv.

4. So kom du nqaij Bacopa monnieri ethanol extract muaj ib tug relaxing nyhuv rau tag nrho cov ntaub so ntswg cais xws li luav thiab guinea npua cais trachea, pulmonary artery thiab aorta, thiab yuav txo tau cov contraction ntawm guinea npua tracheal strips tshwm sim los ntawm histamine nyob rau hauv ib tug npaum li cas ntawm cov tshuaj. . Ntawm lawv, cov txiaj ntsig pom tseeb tshaj plaws yog ntawm guinea npua, tab sis cov qauv tracheal tau so tag nrho. Cov nyhuv relaxing ntawm cov hlab ntsha ntawm cov hlab ntsha tuaj yeem tsis tuaj yeem thaiv los ntawm atropine thiab pracerolol, tab sis cov nyhuv so ntawm cov extract ntawm tracheal specimens tuaj yeem raug thaiv ib nrab los ntawm pracerolol. Indomethacin tuaj yeem thaiv cov ntaub so ntswg uas tshwm sim los ntawm cov nroj tsuag rho tawm, thiab cov nroj tsuag rho tawm muaj tib yam kev so ntawm cov hlab ntsha nrog lossis tsis muaj endothelium. Cov txiaj ntsig tau qhia tias kev so los ntawm Bacopa tuaj yeem koom nrog cov tshuaj prostacyclin thiab -adrenergic receptors. Tsis tas li ntawd, qhov kev so no tsis nyob ntawm qhov ua kom cov endothelial thiab muscarinic receptors.

5. Lwm yam teebmeem Ntxiv rau cov teebmeem kev puas siab puas ntsws, cov tshuaj tiv thaiv kab mob, mob plawv thiab lwm yam teebmeem tshuaj ntawm Bacopa monnieri npaj los yog rho tawm kuj tau soj ntsuam. Cov nyhuv inhibitory ntawm Bacopa monnieri ntawm kev sim mob tau muab piv nrog cov tshuaj tiv thaiv kab mob indomethacin. Cov txiaj ntsig tau pom tias BM ua tau zoo inhibited qhov kev sim inflammatory teb los ntawm inhibiting prostaglandin synthesis thiab ib feem stabilizing lysosomal membrane. Thiab ntawm cov tshuaj tiv thaiv kab mob, Bacopa tsis ua rau mob plab hnyuv. Bacopa monnieri extract tuaj yeem kho ntau hom mob.

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