Ursolic acidyog ib qho phytochemical pom nyob rau hauv ntau yam nroj tsuag, tab sis feem ntau yog txiv apple tev.
Txawm hais tias kev tshawb fawb tshawb fawb yog qhov ua ntej, nws zoo li txo qis cov rog thiab nce cov leeg nqaij thaum noj, thiab txhawb kom muaj roj hlawv thiab tswj cov leeg nqaij thaum yoo mov.
Yav dhau los, nyob rau hauv cov ntaub ntawv ntawm streptozotocin induced ntshav qab zib nas, ursolic acid raws li ib tug kev kho mob sau tseg tias piv nrog rau kev tswj, {{0}}.05 feem pua ntawm cov khoom noj (kwv yees 10mg / kg) tuaj yeem txo cov ntshav qab zib los ntawm 12.3 feem pua hauv 4 lub lis piam. Lwm txoj kev tshawb fawb siv 4 zaug (0.2 feem pua) ntawm cov koob tshuaj hauv 11 lub lis piam. Cov ntshav qabzib tau txo qis mus rau 53 feem pua hauv siab - pab pawg tswj kev noj zaub mov muaj roj (txawm tias nws tseem yog ob npaug ntawm pawg tswj kev noj qab haus huv). Ursolic acid nyiam txo cov ntshav qabzib hauv ib koob- raws li kev nyob ntawm (vim qee qhov kev tshawb fawb tau sim ntsuas qib ntawm ursolic acid nyob rau hauv thaj tsam ntawm 0.05-0.2 feem pua), uas muaj cov txiaj ntsig zoo sib xws rau oleanolic acid.
Nws zoo nkaus li tiv taus saccharification thiab tuaj yeem txo cov kev mob tshwm sim ntawm cov ntshav qab zib uas cuam tshuam nrog hyperglycemia. Ntxiv nrog rau kev tiv thaiv glycosylation, koob tshuaj tsawg ursolic acid ({{0}}}.01 feem pua ntawm cov nas noj) tau raug sau tseg kom txo qis qhov tshwm sim ntawm tus mob ntshav qab zib nephropathy, uas tej zaum yuav yog qhov thib ob los tiv thaiv {{ 2}}cov khoom inflammatory thiab tau raug sau tseg tias ursolic acid muaj tsawg dua atherosclerosis. Nws muab kev tiv thaiv me ntsis ntau dua li qhov sib npaug (0.2 feem pua ntawm cov khoom noj) ntawm resveratrol.
Ursolic acid zoo li nce lipolysis hauv vitro los ntawm cov protein kinase A ua kom thiab qis qis ntawm cov tshuaj hormones lipase (HSL) thiab lipid droplet coated protein A kev ua haujlwm. Kev tswj hwm ntawm cov ntaub so ntswg adipose lipase (ATGL) tau sau tseg hauv adipocytes, uas tsis cuam tshuam nrog PKA.
Hauv cov nas, 100 mg / kg ursolic acid zoo li txo qis qhov nce ntawm triglycerides hauv cov lus teb rau cov rog rog, uas suav tias yog ua tiav los ntawm inhibiting pancreatic lipase; Qhov kwv yees qhov sib npaug tib neeg koob tshuaj yog 16 mg / kg.
Ursolic acid 10mg / kg (rat koob) txo qhov hnyav nce ntawm cov nas noj qab haus huv tau noj ntau- rog noj los ntawm 24 feem pua rau 10.7 feem pua hauv 15 lub lis piam, uas tsis txawv txav ntawm cov tshuaj nquag (sibutramine) 10mg / kg. Txoj kev tshawb no tau sau tseg tias siab -fat induced hloov nyob rau hauv adipokines (ghrelin, leptin) thiab daim siab histology tau normalized nyob rau hauv ob qho tib si pab pawg, thiab ursolic acid yog txuam nrog rau cov insulin ntau ntxiv txheeb ze rau siab - rog tswj thiab kuj txo cov piam thaj.
Cov qauv nas ntawm benign prostatic hyperplasia nrog kev tswj qhov ncauj ntawm 5 mg / kg ursolic acid thiab txhaj tshuaj testosterone pom tau tias inhibition ntawm prostate kev loj hlob zoo ib yam li cov kev tswj hwm nquag (10 mg / kg finasteride), thiab qhov loj ntawm inhibition ntawm Testosterone thiab DHT yog sib npaug rau cov finasteride, tab sis finasteride tau zoo dua los txo cov ntshav ntawm prostate tshwj xeeb antigen (PSA).
Ursolic acid (thiab lwm yam sib txuas hawthorn acid thiab oleanolic acid) yog hu ua angiogenesis inhibitor, uas tuaj yeem tiv thaiv cov hlab ntsha loj los ntawm kev tsim cov hlab ntsha tshiab. Hauv cov hlab ntsha, ursolic acid tshwm sim los ntawm inhibiting PI3K Akt txoj kev thiab nitric oxide induction, inhibiting cellular hloov ua ntej angiogenesis. Cov txiaj ntsig no tau pom nyob rau hauv vivo nrog cov tshuaj tsis yog - tshuaj lom ntawm ursolic acid, uas tseem cuam tshuam qhov kev qhia ntawm MMP2 thiab MMP9 (qhov nruab nrab xav tau rau theem kawg ntawm angiogenesis nkag mus rau cov ntaub so ntswg tshiab).
Vim hais tias cov qog nqaij hlav tshiab xav tau cov ntshav khiav thiab angiogenesis kom muaj sia nyob, cov tshuaj tiv thaiv kab mob qog noj ntshav ntawm no angiogenesis inhibition tam sim no tau kawm. Cov kev tshawb fawb yav dhau los ntawm cov nas uas tau sim nrog ursolic acid tau pom tias qhov ntsuas ntawm vascularization ntawm melanoma hauv ursolic acid 4.25mg / kg (50uml / kg) rau 5 hnub yog 42.03 feem pua ntawm cov hauv pawg tswj hwm ( pab pawg tsis kho).
When rats were fed with 5mg / kg body weight, ursolic acid caused infertility by inhibiting spermatogenesis. Specifically, it breaks the bridge between the cells that are about to become sperm, and then the damaged cells gather to form symbionts in the seminiferous tubules associated with male infertility. But it doesn't seem to cause long-term damage to the testicles.
Ib txoj kev tshawb nrhiav tau taw qhia tias ursolic acid tuaj yeem ua rau cov cell tuag hauv cov hlwb endothelial thaum cov concentration ntau dua 12.5um, thiab cov txheej txheem tuag yog cuam tshuam nrog apoptosis; DNA strand so tau sau tseg tom qab 6 teev ntawm incubation nrog p53.
Tsawg koob tshuaj ursolic acid ({{0}}.2 feem pua kev noj zaub mov) tau muab rau cov nas mob ntshav qab zib uas raug ntxias los ntawm streptozotocin thiab tsis muaj LDL receptor. Nws tau pom tias ursolic acid tuaj yeem txo qhov mob tshwm sim hauv cov ntshav qab zib endothelium los ntawm 53 feem pua. Nws qhia tias nws muaj kev tiv thaiv tab sis tsis tas yuav rov ua haujlwm zoo. Qhov kev tiv thaiv no muaj txiaj ntsig zoo dua li 0.2 feem pua resveratrol. Ursolic acid kuj tseem tuaj yeem txo cov kev tsiv teb tsaws ntawm monocytes mus rau endothelium, uas yog suav tias yog cov lus teb inflammatory.
At 50-100 μ At the concentration of M, ursolic acid can act as an insulin simulant and act on the receptor in 10 μ M has no inherent effect. One of the only studies to note the acute hypoglycemic effect of ursolic acid was an injection of 200 mg / kg, which may act on insulin receptors in this range.
Ursolic acid yog ib yam tshuaj uas tiv thaiv caj ces los ntawm kev yoo mov thiab kho cov leeg nqaij. Thaum cov nas tau noj ntawm {{0}}.14 feem pua thiab 0.27 feem pua ntawm qhov hnyav (tsis paub txog kev noj tag nrho), ursolic acid tuaj yeem tiv thaiv cov leeg nqaij los ntawm cov cim caj ces cuam tshuam rau cov uas kho cov leeg nqaij. Nws tuaj yeem ua rau muaj kev ntxhov siab ntawm cov leeg pob txha los ntawm kev nce cov kev hloov pauv ntawm cov noob caj noob ces, tshwj xeeb tshaj yog cov ntawv sau ntawm IGF-1. Nws tsis zoo li nce qhov kev qhia ntawm IGF-1 hauv cov ntaub so ntswg adipose, qhia tias qhov haujlwm no tshwj xeeb rau cov leeg pob txha. Qhov kev sib xyaw no tau rov ua dua tshiab hauv vitro, qhia txog kev sib xyaw ntawm cov protein thiab ua kom cov leeg nqaij loj, tab sis tsis cuam tshuam rau cov leeg nqaij sib txawv.
Ib txoj kev tshawb nrhiav tau taw qhia tias ursolic acid tuaj yeem ua rau cov cell tuag hauv cov hlwb endothelial thaum cov concentration ntau dua 12.5um, thiab cov txheej txheem tuag yog cuam tshuam nrog apoptosis; DNA strand so tau sau tseg tom qab 6 teev ntawm incubation nrog p53. DNA strand so tom qab tau pom hauv ApoE cov nas uas tsis muaj zog thaum 10 um lossis 30 umursolic acidtau ntxiv rau dej.
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